Two-pore domain K+ channels—molecular sensors
نویسندگان
چکیده
منابع مشابه
Two-pore Domain Potassium Channels in Astrocytes
Two-pore domain potassium (K2P) channels have a distinct structure and channel properties, and are involved in a background K+ current. The 15 members of the K2P channels are identified and classified into six subfamilies on the basis of their sequence similarities. The activity of the channels is dynamically regulated by various physical, chemical, and biological effectors. The channels are ex...
متن کاملMolecular background of leak K+ currents: two-pore domain potassium channels.
Two-pore domain K(+) (K(2P)) channels give rise to leak (also called background) K(+) currents. The well-known role of background K(+) currents is to stabilize the negative resting membrane potential and counterbalance depolarization. However, it has become apparent in the past decade (during the detailed examination of the cloned and corresponding native K(2P) channel types) that this primary ...
متن کاملSerotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex.
The entorhinal cortex (EC) is regarded as the gateway to the hippocampus; the superficial layers (layers I-III) of the EC convey the cortical input projections to the hippocampus, whereas deep layers of the EC relay hippocampal output projections back to the superficial layers of the EC or to other cortical regions. The superficial layers of the EC receive strong serotonergic projections from t...
متن کاملExpression and localization of two-pore domain K(+) channels in bovine germ cells.
Two-pore domain K(+) (K(2P)) channels that help set the resting membrane potential of excitable and nonexcitable cells are expressed in many kinds of cells and tissues. However, the expression of K(2P) channels has not yet been reported in bovine germ cells. In this study, we demonstrate for the first time that K(2P) channels are expressed in the reproductive organs and germ cells of Korean cat...
متن کاملNovel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly.
Ten genes with essential structural features of two-pore domain potassium channels were identified in the genome of Drosophila melanogaster. Two Drosophila two-pore domain potassium subunits displayed substantial amino acid similarity to human TWIK-related acid-sensitive K(+) (TASK) channels (38-43%), whereas all others were less than 26% similar to any human homolog. The cDNAs of Drosophila TA...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2002
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(02)00597-7